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Skin reactions and Covid-19 vaccination

Denpa News To characterize the cutaneous manifestations that can occur after the injection of different types of COVID vaccines, the French Association of Dermatology (SFD) launched the COVACSKIN study. The data was collected anonymously from the patients’ medical records by a dermatologist who participated in the project to provide information on the clinical aspect of the reaction, the time it appeared relative to the injection, sometimes histological data, and it is the evolution in the following days, as well as its recurrence or not during the second or third vaccination dose. 

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Most of the reported reactions followed the first injection of the vaccine (146/196 = 74.5%). The mean time to onset was 5.6 days. Localized reactions (25%) are mostly Teus erythema, edematous, and pruritic (38%) with a large plaque >10 cm (70%). 

Generalized reactions are the most common (90%) with urticaria being the most common (20%). 

The mean healing time of the skin reaction is 19 days according to the first data collected. The precise pathophysiological mechanisms of these skin reactions remain to be elucidated, but they are not allergic reactions. The COVID vaccines are known to be highly immunogenic, which could lead to the reactivation of old or pre-existing skin conditions, such as bullous conditions or psoriasis, or other forms of skin hyperreactivity. However, these reactions remain transient and in no way constitute a contraindication to continued vaccination. The French study confirms the results of three previous studies published on the subject by American, Spanish, and English teams 

Although very significant skin reactions sometimes occur, which can impress both the patient and the doctor, they always disappear spontaneously and without consequences within a few days. Most occur during the first injection and only in 30% of cases recur during the second injection in similar forms, but often of less intensity, which in no way constitutes a contraindication to the continuation of the vaccination.

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